C0002000000bia

Biological test against breast adenocarcinoma cells (MCF-7) of acylated products of 3-methyl-4 thiorhodanine

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Rhodanine and its derivatives are not
only valued for their interesting chemical
properties but also present a wide range of
bioactivities and their chemical and
pharmacological applications have been
investigated. From 3-methyl-4-thiorhodanine
we synthesized S-acylated and C-acylated
products using (some) carboxylic acid
chlorides and the obtained products were
studied the anti-proliferative activity by a
SRB (sulforhodamine B) assay against a
human breast cancer cell line. The results
showed that C-acylated products are better
inhibitors than S-acylated products.

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